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| Player | IP | W | SO | ERA | WHIP | FV | | . | | 1 | Johan Santana | 210 | 15 | 185 | 3.35 | 1.14 | 2.89 | | . | | 2 | Tim Lincecum | 200 | 13 | 225 | 3.25 | 1.19 | 2.82 | | . | | 3 | C.C. Sabathia | 210 | 15 | 190 | 3.35 | 1.16 | 2.8 | | . | | 4 | Roy Halladay | 215 | 14 | 160 | 3.35 | 1.13 | 2 | | . | | 5 | Cole Hamels | 200 | 14 | 180 | 3.5 | 1.16 | 1.74 | | . | | 6 | Dan Haren | 200 | 14 | 180 | 3.35 | 1.19 | 1.71 | | . | | 7 | Jake Peavy | 190 | 12 | 180 | 3.35 | 1.15 | 1.29 | | . | | 8 | Brandon Webb | 215 | 14 | 170 | 3.35 | 1.22 | 1.24 | | . | | 9 | Josh Beckett | 180 | 14 | 175 | 3.4 | 1.23 | 0.89 | | . | | 10 | Ervin Santana | 195 | 13 | 180 | 3.45 | 1.22 | 0.79 | | . | | 11 | Francisco Liriano | 180 | 13 | 175 | 3.5 | 1.21 | 0.54 | | . | | 12 | Chad Billingsley | 190 | 14 | 190 | 3.5 | 1.32 | 0.29 | | . | | 13 | A.J. Burnett | 190 | 14 | 195 | 3.7 | 1.31 | 0.15 | | . | | 14 | Javier Vazquez | 190 | 13 | 185 | 3.75 | 1.27 | -0.18 | | . | | 15 | James Shields | 195 | 13 | 150 | 3.85 | 1.18 | -0.41 | | . | | 16 | Cliff Lee | 190 | 13 | 130 | 3.4 | 1.21 | -0.46 | | . | | 17 | Rich Harden | 150 | 10 | 170 | 3.35 | 1.2 | -0.63 | | . | | 18 | Daisuke Matsuzaka | 190 | 14 | 175 | 3.9 | 1.31 | -0.79 | |
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| | | | | | | | | | | . | | 19 | Scott Kazmir | 180 | 13 | 190 | 4 | 1.3 | -0.8 | | . | | 20 | Kevin Slowey | 190 | 12 | 145 | 3.8 | 1.18 | -0.85 | | . | | 21 | Yovani Gallardo | 180 | 12 | 170 | 3.6 | 1.29 | -0.92 | | . | | 22 | Ryan Dempster | 180 | 13 | 155 | 3.6 | 1.29 | -0.97 | | . | | 23 | Ricky Nolasco | 190 | 12 | 155 | 3.75 | 1.23 | -0.98 | | . | | 24 | Scott Baker | 180 | 12 | 155 | 3.85 | 1.23 | -1.21 | | . | | 25 | Roy Oswalt | 190 | 12 | 145 | 3.8 | 1.22 | -1.26 | | . | | 26 | John Lackey | 190 | 13 | 150 | 3.9 | 1.26 | -1.35 | | . | | 27 | Joba Chamberlain | 150 | 11 | 165 | 3.35 | 1.32 | -1.37 | | . | | 28 | Derek Lowe | 185 | 13 | 115 | 3.45 | 1.25 | -1.42 | | . | | 29 | Edinson Volquez | 180 | 12 | 180 | 3.75 | 1.35 | -1.48 | | . | | 30 | Felix Hernandez | 185 | 12 | 170 | 3.65 | 1.34 | -1.49 | | . | | 31 | Jon Lester | 190 | 14 | 140 | 3.75 | 1.31 | -1.49 | | . | | 32 | Ted Lilly | 185 | 13 | 160 | 4.1 | 1.27 | -1.54 | | . | | 33 | Zack Greinke | 190 | 11 | 170 | 3.7 | 1.3 | -1.54 | | . | | 34 | Jered Weaver | 190 | 12 | 165 | 3.95 | 1.28 | -1.59 | | . | | 35 | Erik Bedard | 170 | 11 | 155 | 3.6 | 1.28 | -1.64 | | . | | 36 | John Danks | 180 | 12 | 140 | 3.6 | 1.28 | -1.67 | | . | | 37 | Matt Cain | 200 | 11 | 175 | 3.8 | 1.32 | -1.8 | | . | | 38 | Wandy Rodriguez | 180 | 12 | 155 | 3.7 | 1.32 | -1.81 | |
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| | | | | | | | | | | . | | 39 | David Price | 170 | 12 | 150 | 3.8 | 1.29 | -1.84 | | . | | 40 | Matt Garza | 185 | 12 | 150 | 3.9 | 1.29 | -2.02 | | . | | 41 | Max Scherzer | 160 | 11 | 160 | 3.75 | 1.31 | -2.02 | | . | | 42 | Gil Meche | 190 | 12 | 160 | 3.75 | 1.35 | -2.06 | | . | | 43 | Hiroki Kuroda | 180 | 12 | 115 | 3.6 | 1.25 | -2.08 | | . | | 44 | John Maine | 175 | 13 | 150 | 4 | 1.33 | -2.2 | | . | | 45 | Adam Wainwright | 175 | 12 | 125 | 3.85 | 1.25 | -2.26 | | . | | 46 | Clayton Kershaw | 170 | 12 | 160 | 3.9 | 1.35 | -2.28 | | . | | 47 | Randy Johnson | 160 | 10 | 140 | 3.7 | 1.25 | -2.36 | | . | | 48 | Justin Verlander | 190 | 12 | 155 | 3.95 | 1.33 | -2.38 | | . | | 49 | Jair Jurrjens | 180 | 12 | 135 | 3.6 | 1.35 | -2.48 | | . | | 50 | Manny Parra | 180 | 12 | 160 | 3.95 | 1.36 | -2.5 | | . | | 51 | Ubaldo Jimenez | 190 | 12 | 160 | 3.85 | 1.38 | -2.56 | | . | | 52 | Justin Duchscherer | 160 | 11 | 100 | 3.75 | 1.18 | -2.6 | | . | | 53 | J.A. Happ | 175 | 11 | 155 | 4 | 1.32 | -2.69 | | . | | 54 | Carlos Zambrano | 195 | 13 | 145 | 4.2 | 1.32 | -2.69 | | . | | 55 | Dustin McGowan | 180 | 12 | 145 | 3.9 | 1.35 | -2.73 | | . | | 56 | Brett Myers | 180 | 12 | 150 | 4.1 | 1.33 | -2.76 | | . | | 57 | Andy Sonnanstine | 180 | 11 | 130 | 3.9 | 1.28 | -2.85 | | . | | 58 | Brandon Morrow | 170 | 12 | 160 | 4.2 | 1.36 | -2.87 | |
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| | | | | | | | | | | . | | 59 | John Smoltz | 150 | 9 | 125 | 3.6 | 1.23 | -2.88 | | . | | 60 | Josh Johnson | 175 | 11 | 150 | 3.85 | 1.36 | -2.95 | | . | | 61 | Aaron Harang | 190 | 11 | 160 | 4.2 | 1.32 | -2.97 | | . | | 62 | Shaun Marcum | 180 | 11 | 145 | 4.35 | 1.26 | -3.04 | | . | | 63 | Chris Young | 170 | 10 | 155 | 4.25 | 1.28 | -3.1 | | . | | 64 | Jonathan Sanchez | 180 | 11 | 170 | 3.95 | 1.42 | -3.16 | | . | | 65 | Chris Carpenter | 160 | 10 | 115 | 3.7 | 1.28 | -3.32 | | . | | 66 | Tommy Hanson | 150 | 10 | 135 | 4 | 1.3 | -3.39 | | . | | 67 | Oliver Perez | 185 | 11 | 170 | 4.4 | 1.36 | -3.43 | | . | | 68 | Sean Gallagher | 175 | 10 | 160 | 4.2 | 1.34 | -3.45 | | . | | 69 | Andy Pettitte | 170 | 12 | 125 | 3.85 | 1.38 | -3.45 | | . | | 70 | Todd Wellemeyer | 190 | 12 | 130 | 4.45 | 1.28 | -3.52 | | . | | 71 | Jorge Campillo | 185 | 11 | 120 | 4.1 | 1.29 | -3.59 | | . | | 72 | Mark Buehrle | 200 | 12 | 120 | 3.95 | 1.36 | -3.72 | | . | | 73 | Phil Hughes | 170 | 10 | 145 | 4.1 | 1.35 | -3.77 | | . | | 74 | Chad Gaudin | 180 | 11 | 135 | 4.35 | 1.31 | -3.8 | | . | | 75 | Joe Saunders | 190 | 13 | 100 | 4.35 | 1.28 | -3.81 | | . | | 76 | Johnny Cueto | 190 | 12 | 170 | 4.65 | 1.39 | -3.88 | | . | | 77 | Jesse Litsch | 190 | 11 | 107 | 4.3 | 1.25 | -3.94 | | . | | 78 | James McDonald | 150 | 10 | 130 | 4.2 | 1.32 | -3.99 | |
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| | | | | | | | | | | . | | 79 | Chris Volstad | 170 | 11 | 130 | 4.2 | 1.36 | -4.08 | | . | | 80 | Paul Maholm | 190 | 11 | 120 | 4.2 | 1.32 | -4.1 | | . | | 81 | Andrew Miller | 170 | 10 | 140 | 3.95 | 1.4 | -4.11 | | . | | 82 | Chien-Ming Wang | 190 | 13 | 100 | 4.3 | 1.32 | -4.12 | | . | | 83 | Armando Galarraga | 190 | 12 | 128 | 4.85 | 1.26 | -4.12 | | . | | 84 | Clay Buchholz | 150 | 11 | 135 | 4.5 | 1.35 | -4.17 | | . | | 85 | Jonathon Niese | 180 | 11 | 145 | 4.25 | 1.4 | -4.2 | | . | | 86 | Bronson Arroyo | 200 | 11 | 160 | 4.4 | 1.4 | -4.27 | | . | | 87 | Mike Pelfrey | 170 | 11 | 130 | 4.1 | 1.41 | -4.37 | | . | | 88 | Kyle Lohse | 190 | 10 | 110 | 3.95 | 1.33 | -4.38 | | . | | 89 | Randy Wolf | 160 | 9 | 119 | 4.1 | 1.33 | -4.64 | | . | | 90 | Jeremy Guthrie | 190 | 10 | 117 | 4.5 | 1.28 | -4.71 | | . | | 91 | Luke Hochevar | 180 | 10 | 140 | 4.5 | 1.36 | -4.77 | | . | | 92 | Boof Bonser | 179 | 9 | 134 | 4.1 | 1.38 | -4.78 | | . | | 93 | Gavin Floyd | 190 | 11 | 125 | 4.55 | 1.34 | -4.82 | | . | | 94 | Anthony Reyes | 165 | 8 | 120 | 4.25 | 1.3 | -4.98 | | . | | 95 | Chad Gaudin | 175 | 9 | 133 | 4.17 | 1.39 | -4.99 | | . | | 96 | Dave Bush | 180 | 10 | 110 | 4.9 | 1.23 | -5.08 | | . | | 97 | Jeremy Bonderman | 170 | 10 | 115 | 4.4 | 1.35 | -5.12 | | . | | 98 | Kevin Millwood | 177 | 9 | 120 | 4.05 | 1.39 | -5.16 | |
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| | | | | | | | | | | . | | 99 | Rich Hill | 150 | 9 | 125 | 4.5 | 1.35 | -5.18 | | . | | 100 | Ian Snell | 190 | 9 | 155 | 4.5 | 1.42 | -5.42 | |
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